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. Author manuscript; available in PMC: 2026 Jun 8.
Published in final edited form as: J Am Chem Soc. 2026 Apr 29;148(18):18579–18585. doi: 10.1021/jacs.6c00508

Table 2.

Investigating Scope: varying pyrazole and diazo-ester partners.

graphic file with name nihms-2172981-t0005.jpg
a

Reaction conditions: 1 (0.2 mmol), 2 (0.1 mmol), [Ir(coe)2Cl]2 (1 mol%), PTC-3 (1.4 mol%), CPA (1.4 mol%), 2-MeTHF (1.0 mL), 40 °C, 21 h. Yields of isolated products are given. Regioisomeric ratios (rr) were determined from 1H NMR analysis of the crude reaction mixtures. Enantiomeric ratios (er) were determined by HPLC analysis on a chiral stationary phase.

b

42 h.

c

The reaction was performed at 60 °C.

d

1.0 equiv. 1a was used.