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. 2026 May 25;13:1841384. doi: 10.3389/fmed.2026.1841384

TABLE 3.

Interocular asymmetry at the last visit and comparison between bilateral and unilateral high myopia.

Variables Overall cohort
(N = 84)
Bilateral high myopia
(n = 62)
Unilateral high myopia
(n = 22)
P-value*
Interocular SE difference (| ΔSE|), D 2.11 ± 2.95 [0.88 (0.50–2.19)] (n = 83) 1.17 ± 1.29[0.81 (0.37–1.50)] 4.89 ± 4.46[4.37 (1.13–6.00)] (n = 21) <0.001
Anisometropia (| ΔSE| ≥ 2.0D), n/N (%) 23/83(27.7%) 9/62(14.5%) 14/21(66.7%) <0.001
Interocular AL difference (| ΔAL|), mm 0.56 ± 0.78[0.25 (0.10–0.64)] (n = 66) 0.37 ± 0.48[0.22 (0.10–0.45)] (n = 52) 1.27 ± 1.25[0.95 (0.31–1.95)] (n = 14) 0.002
Interocular LogMAR difference 0.16 ± 0.30[0.08 (0.00–0.12)] (n = 77) 0.14 ± 0.29[0.04 (0.00–0.12)] (n = 58) 0.24 ± 0.32[0.10 (0.00–0.24)] (n = 19) 0.128

| Δ| represents the absolute difference between both eyes at the last follow-up (e.g., | ΔSE| = | SE_R − SE_L|). Bilateral high myopia: both eyes meet SE ≤ −6.00D at the last follow-up; unilateral high myopia: only one eye meets this criterion. For comparisons between groups of continuous variables: Mann–Whitney U test; for categorical variables: Fisher’s exact test. The Spearman ρ of | ΔSE| and | ΔAL| was 0.629, P < 0.001 (n = 66).