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. 2005 Dec 30;103(2):281–286. doi: 10.1073/pnas.0509849103

Fig. 1.

Fig. 1.

IgGs of MS patient and EAE mice react with MBP in rat brain sections. (A) Western blotting of purified MBP (m) and rat brain tissue homogenate (h) with antigen affinity-purified IgG from a MS patient, a EAE SJL mouse, and with MAB382. (B) Schematic myelin distribution in a rat brain section. (C) Wright's stain of the rat brain section chosen for analysis. D-H were taken from the indicated areas. (D-F) Double-label immunofluorescence of mouse anti-MBP monoclonal antibody MAB382 and catalytic IgG from MS patient. (D) MAB382 (Alexa 546, red). (E) MS (FITC, green). (F) Merge of D and E.(G and H) Immunofluorescence of MAB382 and IgG from EAE SJL mouse on serial sections. (G) MAB382 (Alexa 546, red). (H) IgG from EAE mouse (Alexa 488, green).