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Proteolytic activity of the MS patient and EAE mice antibodies is inhibited by glatiramer acetate (Copaxone). Purified MBP was incubated with either trypsin or IgGs of human (MS) or mouse (EAE) and a variable concentration of glatiramer acetate (Copaxone). The proteolytic activity was calculated as the ratio of degraded and nondegraded MBP measured by the densitometry of Coomassie-stained gel.
