Table 2.
Comparison of grey matter volumes in reward-related regions between CM+ and CM- adolescents at ages 14 and 18 (N = 634)
| Region | Cluster level | Peak voxel | MINI coordinates | ||||
|---|---|---|---|---|---|---|---|
| k | p Value(FWE corr) | t Value | p Value uncorrected | x | y | z | |
| Regions where GMV are smaller in CM+ than in CM− participants at age 14 | |||||||
| Insula R | 1818 | 3.815e−04 | 5.06 | 2.814e−07 | 28 | −20 | 20 |
| Sup temp pole R | 4.21 | 1.264e−05 | 40 | −12 | −10 | ||
| Rolandic operculum R | 4.0 | 2.986e−05 | 40 | −18 | 22 | ||
| Med OFC L | 1681 | 5.995e−04 | 4.86 | 7.561e−07 | −20 | 18 | −14 |
| Amygdala L | 4.05 | 2.896e−05 | −30 | 2 | −20 | ||
| Sup temp pole /parahippocampal gyrus L | 4.00 | 3.513e−05 | −30 | 4 | −22 | ||
| Post OFC L | 3.92 | 4.830e−05 | −16 | 22 | −21 | ||
| Putamen L | 3.26 | 5.613e−04 | −22 | 18 | 2 | ||
| Pg ACC L | 4684 | 1.547e−07 | 4.76 | 1.188e−06 | 0 | 48 | 6 |
| Med sup frontal lobe L | 4.55 | 3.303e−06 | −12 | 51 | 12 | ||
| Olfactory /Accumbens bilat | 4.26 | 1.179e−05 | 0 | 14 | −16 | ||
| Pg ACC R | 3.86 | 6.147e−05 | 10 | 46 | 12 | ||
| Med OFC R | 3.25 | 6.078e−04 | 9 | 42 | −9 | ||
| Paracentral lobule L | 874 | 0.012 | 4.72 | 1.437e−06 | −2 | −28 | 50 |
| Cingulate mid L | 3.82 | 7.348e−05 | −8 | −27 | 38 | ||
| Cingulate mid R | 3.52 | 2.324e−04 | 8 | −22 | 38 | ||
| Insula L | 568 | 0.045 | 3.67 | 1.302e−04 | −42 | −9 | −46 |
| Regions where GMV are smaller in CM+ than in CM− participants at age 18 | |||||||
| Insula R | 2714 | 2.945e–05 | 5.17 | 1.610e−07 | 30 | −20 | 18 |
| Rolandic operculum R | 4.70 | 1.599e−06 | 39 | −18 | 22 | ||
| Sup temp pole/Parahippocampal gyrus R |
4.24
|
1.108e−05
|
45
|
0
|
−15
|
||
| Amygdala R | 4.27 | 1.505e−05 | 30 | 3 | −18 | ||
| Fusiform gyrus R | 3.86 | 5.599e−05 | 38 | −15 | −27 | ||
| OFC/putamen L | 3930 | 1.345e–06 | 5.02 | 3.458e−07 | −20 | 18 | −12 |
| Med sup frontal lobe R | 4.27 | 1.154e−05 | 8 | 48 | 2 | ||
| Rectus R | 4.23 | 1.330e−05 | 3 | 14 | −21 | ||
| Med OFC L | 4.13 | 2.062e−05 | −2 | 33 | −14 | ||
| Insula L | 4.02 | 3.332e−05 | −26 | 14 | −20 | ||
| Med OFC R | 3.98 | 3.833e−05 | 4 | 34 | −14 | ||
| Pg ACC R | 3.87 | 5.901e−05 | 18 | 45 | 12 | ||
| Rectus L | 3.51 | 2.441e−04 | −14 | 34 | −14 | ||
| Cingulate mid L | 1229 | 0.0026 | 4.57 | 2.905e−06 | −2 | −22 | 46 |
| Paracentral lobule L | 4.44 | 5.394e−06 | −2 | −28 | 50 | ||
| Cingulate mid R | 3.58 | 1.823e−04 | 8 | −22 | 38 | ||
Note: Height threshold at p < 0.001 uncorrected. p values in bold are statistically significant at p < 0.05 Family-Wise Error (FWE) corrected; Extent threshold at p < 0.05 (FWE) corrected (k > 500 voxels).
Abbreviations: CM+ = self-report of childhood maltreatment; CM- = no childhood maltreatment; k = cluster size, expressed in number of voxels; MNI = Montreal Neurological Institute coordinates in millimeters; R = right; L = left; bilat = bilateral; med = medial; mid = middle; pg = pregenual; sup = superior; temp = temporal; GMV = grey matter volume; MNI: Montreal Neurological Institute (coordinates in mm).