Table 1.
Patient characteristics in the total patient population by country
| Characteristic, n (%) or mean ± SD or median (IQR) | France (890 pts, 9 sites) |
Spain (454 pts, 5 sites) |
Germany (362 pts, 6 sites) |
Italy (300 pts, 4 sites) |
Austria (176 pts, 2 sites) |
p value |
|---|---|---|---|---|---|---|
| Age (years) |
80.1 ± 7.0 81.0 (76.0, 85.0) |
80.7 ± 6.4 81.0 (77.0, 85.0) |
79.6 ± 6.6 81.0 (76.0, 84.0) |
81.6 ± 4.9 82.0 (79.0, 85.0) |
80.1 ± 6.4 81.0 (77.8, 84.0) |
< 0.001 |
| Female gender | 344 (38.9) | 189 (41.6) | 133 (36.7) | 132 (45.8) | 61 (34.7) | 0.070 |
| Body mass index (kg/m2) |
27.6 ± 5.1 27.0 (24.2, 30.5) |
28.0 ± 5.3 27.4 (24.7, 30.4) |
27.1 ± 4.5 26.6 (24.1, 29.7) |
26.8 ± 4.5 26.5 (23.5, 29.1) |
27.9 ± 4.8 27.0 (24.7, 30.5) |
0.008 |
| Aortic valve-related symptoms | ||||||
| Dizziness with exertion | 56 (6.4) | 228 (50.2) | 62 (17.1) | 60 (21.5) | 112 (63.6) | < 0.001 |
| (Pre-)syncope | 52 (6.0) | 53 (11.7) | 40 (11.0) | 31 (11.1) | 28 (15.9) | < 0.001 |
| NYHA class III or IV | 443 (50.8) | 262 (57.7) | 233 (64.9) | 171 (61.3) | 107 (60.8) | < 0.001 |
| Angina CCS 3 or 4 | 19 (2.2) | 17 (3.7) | 15 (4.2) | 24 (8.6) | 21 (11.9) | < 0.001 |
| Risk scores and frailty | ||||||
| EuroSCORE II |
4.6 ± 6.5 2.4 (1.6, 5.0) |
3.8 ± 2.6 3.4 (2.0, 4.3) |
6.8 ± 7.3 4.3 (2.1, 8.1) |
6.0 ± 6.5 3.5 (2.2, 6.8) |
4.0 ± 3.8 2.8 (1.8, 4.7) |
< 0.001 |
| Frailty, severe | 11 (1.3) | 29 (6.4) | 19 (5.2) | 5 (1.8) | 4 (2.3) | < 0.001 |
| Impaired mobility | 52 (5.9) | 76 (16.7) | 100 (27.6) | 14 (5.0) | 30 (17.0) | < 0.001 |
| Cognitive deficit | 20 (2.3) | 23 (5.1) | 17 (4.7) | 10 (3.6) | 6 (3.4) | 0.070 |
| Comorbidities | ||||||
| Prior MI | 92 (10.5) | 79 (17.4) | 42 (11.6) | 37 (13.2) | 51 (29.0) | < 0.001 |
| Peripheral artery disease | 165 (18.8) | 43 (9.5) | 31 (8.6) | 57 (20.3) | 31 (17.6) | < 0.001 |
| Diabetes mellitus | 229 (26.1) | 194 (42.7) | 111 (30.7) | 75 (26.7) | 65 (36.9) | < 0.001 |
| PH, severea | 26 (3.5) | 30 (7.2) | 31 (8.8) | 17 (7.2) | 21 (15.4) | < 0.001 |
| Renal insufficiency | 225 (25.5) | 107 (23.6) | 95 (26.2) | 87 (31.0) | 51 (29.0) | 0.213 |
| Prior pacemaker | 53 (6.3) | 31 (6.8) | 27 (7.7) | 12 (4.4) | 14 (8.1) | 0.445 |
CCS Canadian Cardiovascular Society, IQR interquartile range, MI myocardial infarction, NYHA New York Heart Association, SD standard deviation, pts patients, PH pulmonary hypertension
aMean pulmonary arterial pressure > 55 mmHg