Table 3. Distribution of TLR4 polymorphisms in severe malaria patients and controls.

		Controls
	Severe malaria patients	Asymptomatic, P. falciparum-infected	Healthy	P,* patients vs. healthy controls
Number	290	290	290
Prevalence TLR4 Asp299Gly, % (no.)	24.1 (70)	22.8 (66)	17.6 (51)	0.046
Heterozygous, % (no.)	22.4 (65)	22.1 (64)	16.2 (47)	0.04
Homozygous, % (no.)	1.7 (5)	0.7 (2)	1.4 (4)	1
Allele frequency	0.129	0.117	0.095	0.06†
Prevalence TLR4 Thr399Ile, % (no.)	6.2 (18)	4.1 (12)	2.4 (7)	0.03
Heterozygous, % (no.)	5.9 (17)	3.8 (11)	2.4 (7)	0.04
Homozygous, % (no.)	0.3 (1)	0.3 (1)	0	1
Allele frequency	0.033	0.022	0.012	0.02†

^*McNemar test.

^†χ² test.