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Imaging hypoxia by using ODD-Luc mice. (A) Bioluminescent images (anterior view) of ROSA26 Luc/+, ODD-Luc/+, and +/+ FVB mice. (B) Bioluminescent images (posterior view) of the same two ROSA26 ODD-Luc/+ mice breathing 21% or 8% oxygen. For the latter, the ambient oxygen was reduced from 21% to 8% over 1 h and maintained at 8% for an additional 4 h. Color bar indicates photons/(cm2·sec·steradian) with minimum and maximum threshold values.
