Table 1. Atherosclerotic lesion size at the aortic root of parental B6.LDLR–/– and FVB.LDLR–/– mice and F1 and F2 offspring.
| Genetic background
|
Lesion size, μm2
|
|
|---|---|---|
| Females | Males | |
| B6.LDLR-/- | 289,708 ± 49,942 (9) | 122,457 ± 36,137 (10) |
| FVB.LDLR-/- | 10,344 ± 2,807 (9) | 18,268 ± 5,782 (12) |
| F1 (mB6xfFVB) | 75,086 ± 24,173 (12) | 49,704 ± 27,765 (13) |
| F1 (mFVBxfB6) | 80,412 ± 19,460 (20) | 50,463 ± 22,682 (16) |
| F2 (mB6xfFVB) | 91,698 ± 78,986 (106) | 70,663 ± 47,958* (110) |
| F2 (mFVBxfB6) | 86,668 ± 70,544 (110) | 49,555 ± 42,084* (118) |
F1 and F2 animals were generated by crossing male B6.LDLR-/- to female FVB.LDLR-/- mice (mB6xfFVB) and by intercrossing the resulting F1 or by crossing male FVB.LDLR-/- to female B6.LDLR-/- mice (mFVBxfB6) and intercrossing the resulting F1. Values in parentheses indicate the number of mice with measurements of atherosclerosis per group. *, P < 0.001 between groups.