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17-AAG inhibits Raf signaling and induces a G1 growth arrest. The 24-h treatment with 100 nM 17-AAG caused G1 block in SK-Mel-28 and SK-Mel-31 cell cycle and an increase in sub-G1 fraction. In parallel, 24 h of exposure to indicated concentrations of 17-AAG caused down-regulation in expression of phospho-MAPK, cyclin D1, and hypophosphorylation Rb in both cell lines and had no effect on MAPK or p85 PI3-kinase expression.
