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. 2005 Dec 21;103(1):57–62. doi: 10.1073/pnas.0609973103

Fig. 7.

Fig. 7.

17-AAG causes degradation of mutant B-Raf and inhibited the growth of SK-Mel-28 xenografts. (A) Mice with established tumors were treated for 3 consecutive days with 17-AAG (0, 25, 50, or 100 mg/kg) or the egg phospholipid vehicle alone as a control. At 12 h after the third treatment, mice were killed and tumor tissue was homogenized in 2% SDS lysis buffer and analyzed by immunoblotting for various cellular markers as indicated. (B) 17-AAG inhibited the growth of SK-Mel-28 xenografts in a dose-dependent manner.