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Diagrammatic alignment of human somatic ACE (1306 amino acids) and AnoACE9 (1225 amino acids). The hatched boxes represent the N and C domain active site regions. Filled boxes are the C-terminal hydrophobic potential membrane anchor regions. AnoACE9 has a very short potential cytoplasmic region and a sequence gap relative to the human enzyme on the N terminal side of the putative transmembrane region. Arrows indicate potential secretase recognition sequences.
