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. 2006 Jan 3;4(1):e11. doi: 10.1371/journal.pbio.0040011

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Copyright: © 2006 Rechkoblit et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) View of the (oxoG6-C7-T8)•(A12-G13) segment plus dCTP and Y12 in the modified ternary complex. The aromatic ring of Y12 is packed against the sugar ring of the incoming dCTP.

(B) View of (A) looking down the helix axis.

(C) View of the (oxoG6-C7-T8)•(A12-G13-C14) segment and Y12 in the postinsertion binary complex.

(D) View of (C) looking down the helix axis.

(E) Superposition of the (oxoG6-C7-T8)•(A12-G13) segment plus dCTP and Y12 of the modified ternary complex (in color) with the (oxoG6-C7-T8)•(A12-G13-C14) segment and Y12 of the posinsertion binary complex (in beige) by the oxoG6-C7-T8 and G6-C7-T8 template strands segments. Note the relative positioning of the sugar ring of dCTP/C14 and the aromatic ring of Y12 in the two complexes.