Table 1.

Point mutations identified in the APT genomic sequence in Ppmsh2Δ 2-FA resistant clones

Genomic positiona	Amino acidb	DNA mutation	Consequencec
1447	28	GGC→TGC	Intron I splicing
1462	33	GAT→TAT	D→T
1559	65	GGT→GAT	G→D
1687	Intron II	AGG→ATG	Intron II splicing
2121	108	GGT→GAT	G→D
2195	133	GCC→ACC	A→T
2464	150	GCG→GAG	A→E
2485	157	TGC→TAC	C→Y

^aPosition 1 corresponds to the first nucleotide in the genomic PpAPT sequence DQ117987.

^bPosition 1 corresponds to the ATG codon in the PpAPT protein.

^cUniversal genetic code for amino acid.