Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Hydroamination of Various Alkynes with Aniline
| % yieldb |
|||||
|---|---|---|---|---|---|
| entry | R1, R2 | 6/7 | time (h) | 1b | 2 |
| 1 | Et, Et | NA | 24 | >95 (83c) | >95 |
| 2 | n-Pr, Me | 1:1 | 24 | >95 | 71 |
| 3 | Ph, H | only 6 | 2 | 77 (65c) | 66 |
| 4 | n-Pr, H | only 6 | 2 | 70 | 62 |
| 5 | Ph, Me | only 7 | 24 | NR | 19 |
Identical results were obtained when the reaction was run in C6D6 or C7H8.
Yields are given as NMR yields. Hydrolysis to the corresponding ketone was used to confirm these assignments.
Isolated yield of imine reduction product.
