Table 5.
Results of 2-SNP haplotype analysis in a) European Americans cases and controls, and b) African American cases and controls. Empiric P-values are based on 1,000 or 10,000 permutations; only haplotypes with at least one P-value < 0.05 are shown. P-values that were significant after adjusting for multiple (45) comparisons are in bold font; ns, not significant (P ≥ 0.05).
| Locus 1 | Locus 2 | Asthma vs. Controls | +SPT to Any Allergen vs. Controls | +SPT Molds vs. Controls |
| a) European Americans | ||||
| IL13_-1112 | IL4_+3017 | ns | ns | 0.0128 |
| IL13_+1923 | IL13_130 | <10-4 | 0.0011 | 0.0121 |
| IL13_130 | SNP2 | ns | 0.0295 | 0.0101 |
| IL4_-589 | SNP2 | <10-4 | 0.0004 | 0.0026 |
| SNP4 | <10-4 | <10-4 | 0.0005 | |
| IL4_+3017 | 0.0003 | 0.0030 | 0.0269 | |
| IL4_+8374 | <10-4 | <10-4 | 0.0002 | |
| SNP7 | 0.0021 | 0.0279 | 0.0335 | |
| SNP8 | 0.0002 | 0.0072 | 0.0155 | |
| SNP2 | SNP4 | ns | 0.0240 | 0.0042 |
| IL4_+3017 | ns | 0.0131 | <10-4 | |
| IL4_+8374 | ns | 0.0252 | 0.0054 | |
| SNP7 | ns | ns | 0.0019 | |
| SNP8 | ns | ns | 0.0128 | |
| IL4_+3017 | SNP7 | ns | ns | 0.014 |
| SNP7 | SNP8 | ns | ns | 0.014 |
| b) African Americans | ||||
| IL13_-1112 | IL13_+1923 | ns | ns | 0.009 |
| IL4_+3017 | 0.034 | ns | 0.005 | |