Figure 5.

Histologic analyses with H&E staining on irradiated murine lung tissue. Three mice from each group were checked. Representative slides are shown for (a) unirradiated control mice at 3 weeks after sham-irradiation; (b) untreated mice at 3 weeks after 10 Gy irradiation; (c) CAPE-treated mice at 3 week after irradiation 10 Gy irradiation; (d) unirradiated control mice at 12 weeks after sham-irradiation; (e) untreated mice at 12 weeks after 10 Gy irradiation; (f) CAPE-treated mice at 12 week after irradiation 10 Gy irradiation. These demonstrate that interstitial pneumonia with increased acute inflammatory infiltrate in the interstitium was detected at 3 weeks and 12 weeks after irradiation. CAPE treatment attenuated the extent of inflammation. Magnification × 200