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Analysis of the contribution to alignment accuracy made by different algorithmic variants. Kalign-default uses Wu-Manber approximate string matching, while Kalign-ktuple, Mafft-fast, Muscle-fast, and ClustalW-quicktree use exact k-tuple matching. The default Kalign Wu-Manber based algorithm becomes more accurate than other methods at high evolutionary distances. The alignments consisted of 50 simulated sequences.
