PDAC	pancreatic ductal adenocarcinoma
CFR	case fatality rate
PAXG	cisplatin, nab-paclitaxel, capecitabine, and gemcitabine
mFOLFIRINOX	5-fluorouracil with leucovorin, irinotecan, and oxaliplatin
ICIs	immune checkpoint inhibitors
NGS	next-generation sequencing
CGP	comprehensive genomic profiling
ctDNA	circulating tumor DNA
MRD	minimal residual disease
RFS	recurrence-free survival
OS	overall survival
SC	single-cell
MO	multiomics
SPT	spatial proteomics and transcriptomics
AI	artificial intelligence
TME	tumor microenvironment
WHO	World Health Organization
EFS	event-free survival
CSCs	cancer stem cells
ECM	extracellular matrix
NCI	National Cancer Institute
SEER	Surveillance, Epidemiology, and End Results
HDI	Human Development Index
PanIN	pancreatic intraepithelial neoplasia
IPMN	intraductal papillary mucinous neoplasm
WGS	Whole-genome sequencing
MRI	magnetic resonance imaging
MRCP	magnetic resonance cholangiopancreatography
EUS	endoscopic ultrasound
MPD	pancreatic duct diameter
PD	pancreatoduodenectomy
DPPHR	duodenum-preserving pancreatic head resection
CT	computed tomography
FNB	fine needle biopsy
FNA	fine needle aspiration
BR	borderline resectable
LA	locally advanced
RCT	randomized clinical trial
pCR	complete pathologic response
MPR	major pathologic response
pPR	partial pathologic response
pNR	pathologic non-response
R	resectable
NA	neoadjuvant
DMFS	distant metastasis-free survival
PFS	Progression-free survival
LC	local control
GEM/nab-PTX	gemcitabine/nab-paclitaxel
SBRT	stereotactic Body Radiation Therapy
iHD-SBRT	isotoxic High-Dose SBRT
SABR	stereotactic Ablative Radiotherapy
GEM/CAP	gemcitabine/capecitabine
ESMO	European Society For Medical Oncology
PET	positron emission tomography
ITH	intratumor heterogeneity
CRC	colorectal cancer
HRC	high-relapse cells
VAFs	variant allele frequencies
CTCs	circulating tumor cells
NSLSC	non-small cell lung cancer
TNBC	triple negative breast cancer
Hh	Hedgehog
ICB	immune checkpoint blockade
dMMR	mismatch repair deficient
MSI-H	microsatellite instability-high
ORR	overall response rate
TAMs	tumor-associated macrophages
MDSCs	myeloid-derived suppressor cells
Tregs	regulatory T cells
MSK	Memorian Sloan Kettering
PPV	positive predictive value
NPV	negative predictive value
SoC	standard of care
PCR	polymer chain reactions
mPCR	multiplex PCR
ACT	adjuvant chemotherapy
mDFS	median DFS
CAPP-seq	cancer personalized profiling by deep Sequencing
WES	whole exome sequencing
NAC	neoadjuvant chemotherapy
FDA	US Food and Drug Administration
TSO500	Illumina TruSight Oncology 500
SNVs	single nucleotide variants
indels	short insertions and deletions
CNVs	copy Number variants
CAFs	cancer-associated fibroblasts
cfDNA	cell-free DNA
TAN	tumor-associated neutrophil
DC	dendritic cells
NK cells	natural killer cells