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. 2026 Jun 4;27(11):5080. doi: 10.3390/ijms27115080
AAV Adeno-associated viral vector
Ab Antibody
ADA Anti-drug antibodies
AMD Age-related macular degeneration
ANG2 Angiopoietin-2
C Carboxy-terminus
CDR Complementarity-determining region
CH Constant domain of the heavy chain
CL Constant domain of the light chain
CNAR Constant domain of IgNAR
CNV Choroidal neovascularization
EAU Experimental autoimmune uveitis
ERG Electroretinography
Fab Fragment antigen-binding
FDA The U.S. Food and Drug Administration
Fc Fragment crystallizable
FR Framework region
hcAb Heavy-chain-only antibody
HV Hypervariable region
ICOSL Induced costimulatory ligand
IgG Immunoglobulin G
IgNAR Immunoglobulin new antigen receptor
IL Interleukin
IL-1β Interleukin-1 beta
IL-6 Interleukin-6
IL-8 Interleukin-8
i.p. Intraperitoneal
LOX-1 Lectin-like oxidized low-density lipoprotein receptor-1
LV Lentiviral vector
mAb Monoclonal antibody
nAMD Neovascular age-related macular degeneration
NHP Non-human primate
OCT Optical coherence tomography
OIR Oxygen-induced retinopathy
RPE Retinal pigment epithelium
scFab Single-chain Fab
scFv Single-chain variable fragment
sdAb Single-domain antibody
STAT3 Signal transducer and activator of transcription 3
TCE T-cell epitope
TNFα Tumor necrosis factor alpha
VEGF Vascular endothelial growth factor
VEGFA Vascular endothelial growth factor A
VEGFR Vascular endothelial growth factor receptor
VH Variable domain of the heavy chain
VHH Variable heavy domain of heavy chain
VL Variable domain of the light chain
VNAR Variable new antigen receptor