Table 2.
Baseline characteristics of subgroups by hypertension status and use of diuretics at baseline
| Characteristics | Overall |
Uncontrolled HTN |
Controlled HTN |
Diuretics, yes |
Diuretics, no |
|---|---|---|---|---|---|
| N = 586 | n = 197 (33.6) | n = 389 (66.4) | n = 209 (35.7) | n = 377 (64.3) | |
| Female, n (%) | 196 (33.4) | 56 (28.4) | 140 (36.0) | 65 (31.1) | 131 (34.7) |
| Age, yrs (SD) | 63.8 (11.3) | 65.4 (9.4) | 63.1 (12.0) | 66.3 (8.7) | 62.5 (12.3) |
| T2D status, n (%) | 414 (70.6) | 161 (81.7) | 253 (65.0) | 174 (83.3) | 240 (63.7) |
| HbA1c, % (SD) | 7.0 (1.3) | 7.2 (1.3) | 6.8 (1.3) | 7.4 (1.3) | 6.7 (1.3) |
| BMI, kg/m2 (SD) | 29.9 (5.5) | 30.6 (5.2) | 29.6 (5.6) | 31.3 (5.7) | 29.1 (5.2) |
| Serum aldosterone, pmol/l, median (range) | 125.5 (3–1984) | 132.1 (3–821) | 124.3 (3–1984) | 131.2 (3–781) | 123.2 (3–1984) |
| UACR, mg/g, (median, IQR) | 426 (205.3–889.5) | 558.7 (246.5–1059.7) | 380.5 (187.3–828.3) | 422.5 (187.5–872.2) | 432.3 (222.3–902.0) |
| SBP, mm Hg (SD) | 133.8 (15.7) | 142.7 (15.0) | 129.2 (14.0) | 135.0 (16.2) | 133.1 (15.4) |
| eGFR ml/min per 1.73 m2 (SD) | 51.9 (16, 17.7) | 50.7 (17.0) | 52.6 (18.1) | 50.8 (16.5) | 52.6 (18.4) |
| NT-proBNP, ng/L (SD) | 309.7 (625.4) | 367.1 (580.4) | 280.4 (645.9) | 320.4 (501.7) | 303.4 (607.5) |
BMI, body mass index; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; HTN, hypertension; IQR, interquartile range; NT-proBNP, N-terminal pro-B-type natriuretic peptide; SBP, systolic blood pressure; T2D, type 2 diabetes; UACR, urine albumin-to-creatinine ratio.
Missing baseline UACR data for 3 patients were not included in the subgroup analysis.