Table 2.

Examples of cross-domain coupling.

Primary domain	Example secondary interaction	Mechanistic consequence
Dysautonomia	Immune activation	Sympathetic-mediated inflammatory amplification
Mitochondrial dysfunction	Endothelial dysfunction	Impaired oxygen delivery and oxidative stress
Gut dysbiosis	Immune activation	LPS-mediated cytokine signaling
Mast cell activation	Autonomic instability	Histamine-driven tachycardia
Neuroendocrine dysregulation	Mitochondrial dysfunction	Altered metabolic substrate utilization