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. 2026 May 29;17:1817729. doi: 10.3389/fendo.2026.1817729

Table 2.

Hazard ratios of selected features for osteopenia.

Feature Univariate HR Univariate 95% CI Univariate P-value Multivariate HR Multivariate 95% CI Multivariate P-value
Age 1.01 1.00-1.02 0.010 0.99 0.98-1.01 0.365
Menopause 20.71 9.82-43.66 <0.001 31.5 13.85-71.63 <0.001
UA (umol/L) 1.00 1.00-1.00 0.001 1.00 1.00-1.01 0.157
TP (g/L) 1.04 1.02-1.06 <0.001 1.05 1.02-1.07 <0.001
CHOL (mmol/L) 1.13 1.05-1.21 0.002 0.51 0.36-0.72 <0.001
HDLC (mmol/L) 1.56 1.22-1.99 <0.001 6.32 1.88-21.27 0.003
LDLC (mmol/L) 1.13 1.04-1.22 0.003 2.21 1.57-3.12 <0.001
TPINP (ng/mL) 1.01 1.00-1.01 <0.001 1.00 0.99-1.00 0.132
β-CTX (ng/mL) 3.04 2.26-4.08 <0.001 2.39 1.55-3.69 <0.001
VITD (ng/mL) 1.02 1.02-1.03 <0.001 1.02 1.01-1.03 <0.001
HGB (g/L) 0.99 0.98-1.00 0.03 0.94 0.91-0.97 <0.001
LYM (×10~9/L) 1.29 1.10-1.52 0.002 1.00 0.51-1.95 0.993
MONO (×10~9/L) 3.97 1.87-8.43 <0.001 23.89 2.44-234.42 0.006

The Cox proportional hazard model was used to calculate HR and 95% CI. Multivariable analysis was done based on significant factors from the univariable analysis.