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. 2006 Jan 12;116(2):447–455. doi: 10.1172/JCI26523

Figure 2.

Figure 2

Leptin blockade during adoptively transferred EAE with either anti-leptin Abs or ObR:Fc chimera reduces the clinical severity of EAE. (A) Mean clinical score of SJL/J female mice treated with anti-mouse leptin Abs injected either from day –1 to day 1 or on days 8–11 (100 μg/d i.p.). Leptin blockade significantly reduced clinical score and body weight loss (see Table 1). Data are from 1 representative experiment of 3. #P = 0.02, day –1 to day 1, and **P = 0.001, days 8–11, versus PBS or control Ig; ‡P = 0.02, day –1 to day 1 versus days 8–11. (B) Mean clinical score of SJL/J female mice treated with mouse ObR:Fc chimera injected either from day –1 to day 1 or on days 8–11 (100 μg/d i.p.). Data are from 1 representative experiment of 3. **P = 0.001, day –1 to day 1 and days 8–11 versus control Ig.