Skip to main content
. 2006 Jan 12;116(2):447–455. doi: 10.1172/JCI26523

Figure 5.

Figure 5

In vivo leptin neutralization with anti-mouse leptin Abs inhibits IFN-γ production and induces the secretion of IL-4 and IL-10 regulatory cytokines. (A and B) IFN-γ secretion of lymph node–derived T cells was inhibited by anti-leptin treatment when T cells were stimulated with the myelin antigen PLP139–151 (A) and by anti-CD3ε (B). (C and D) IL-4 secretion of lymph node–derived T cells was enhanced by anti-leptin treatment when T cells were stimulated with the myelin antigen PLP139–151 (C) and by anti-CD3ε (D). (E and F) IL-10 secretion of lymph node–derived T cells was markedly increased by anti-leptin treatment when T cells were stimulated with the myelin antigen PLP139–151 (E) and by anti-CD3ε (F). (A, C, and E) #P = 0.02, day –1 to day 1 and days 8–11, and **P = 0.001, days 8–11, versus control Ig. Data are from 1 representative experiment of 3. (B, D, and F) #P = 0.02, **P = 0.001, *P = 0.002, † P = 0.04 versus control Ig.