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. 2006 Jan 12;116(2):447–455. doi: 10.1172/JCI26523

Figure 8.

Figure 8

Leptin neutralization suppresses ICAM-1 and OX-40 expression on CD4+ cells but upregulates VLA-4 in mice with EAE. (A) Flow cytometric analysis of cell-surface ICAM-1 molecules on CD4+ T cells from ObR:Fc-treated mice and controls (left) and mean fluorescence intensity (MFI) from 3 independent experiments (right). (B) OX-40 surface expression was also reduced by ObR:Fc treatment. (C) VLA-4 expression was enhanced by ObR:Fc treatment, particularly on CD4+ T cells at high intensity. #P = 0.02, *P = 0.002, † P = 0.04 versus control Ig.