Skip to main content
. 2026 Apr 16;6(6):101217. doi: 10.1016/j.xgen.2026.101217

Figure 6.

Figure 6

Annotation transfer across EoE datasets and disease conditions

(A) Expression profiles of differentially ranked HRGs that distinguish ALOX15+ from SPP1+ macrophages. “ALOX15 specific” denotes highly ranked HRGs in ALOX15+ macrophages (rank < 30) and low relevance in others (mean rank > 200). “ALOX15 diff HRG” represents HRGs that are highly ranked in contrasting cell types but not ALOX15+ macrophages.

(B) Expression profiles of differentially ranked HRGs between PRDM16+ dendritic cells and CD1C + cDC2B cells.

(C) Expression patterns of top ILC2-specific HRGs across immune cell populations. Genes were compared between ILC2s and Th2 cells.

(D) Expression patterns of cycling-associated HRGs across proliferating cell populations.

(E) Annotation transfer correspondence between the AtlasEoE25 dataset (72 cell types) and the Morgan et al. dataset78 (eight cell types). Color bar: column-wise proportion.

(F and G) (F) Cell type composition across disease conditions in the Clevenger et al. dataset46 and (G) the Morgan et al. dataset. EoE, eosinophilic esophagitis; GERD, gastroesophageal reflux disease; and HC, healthy.