Table 2.

Protein mediators of endotoxin-related lung function changes and summary of mediation analysis results

Protein Names	IGL c3728_light_IGKV4-1_IGKJ1	Epididymis luminal protein 180
Protein ID	A0A5C2G374	B6EDE2
P-value of HDMT	9.41 × 10− 6	6.83 × 10− 6
P-value of Modified DACT	1.42 × 10− 5	8.71 × 10− 6
Average causal mediation effect (95% CI)	−0.73 (−1.29, −0.29)	−0.717 (−1.21, −0.31)
Average direct effect (95% CI)	−0.82 (−2.55, 0.69)	−0.827 (−2.63, 0.69)
Total effect (95% CI)	−1.54 (−3.31, −0.03)	−1.544 (−3.27, −0.06)
Proportion mediated (p-value)	46.9% (0.05)	46.4% (0.04)

Definition of abbreviations CI Confidence Interval, DACT divide-aggregate composite-null test, HDMT  high dimensional mediation analysis