Figure 1.
Pyrene derivatives of RNA examined in this study. (A) Uridine nucleotide with the A5 tether (16). (B) Pyrene derivatives A2–A7 and T5–T10. The A4 and T7 tethers were additionally examined in their unsaturated forms A4U and T7U. Pyrene-modified adenosines and cytidines were also examined in this study. (C) Preparative reactions of RNA amino groups with a pyrene STP ester. See Supplementary Data for all STP ester structures.