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Connections of the chemical compounds. (A) Relationship between the number of incoming connections (ci) and the number of outgoing ones (co) for the chemical compounds. (B) Relationship between the total number of connections for a compound (c) and its distance (d) to the central metabolism (CM). 'No CM' indicates that there is no pathway to the CM. In both cases, the radii of the circles are proportional to the number of elements (in a logarithmic scale).
