Figure 3.

Relationship between chemical properties of the compounds and their position in the network. (A) Relationship between molecular weights of the compounds and their distance to the central metabolism (CM). (B,C) Relationship between water solubility of the compounds and their distance to the CM. (B) Compounds for which it was possible to obtain a numerical value for solubility. (C) Compounds for which the solubility was described qualitatively (soluble, slightly soluble and insoluble). The bars represent the number of compounds in each category of solubility, at a given distance from the CM. (d = −1 indicates that there is no pathway to the CM).