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. 2003 Oct;4(10):944–947. doi: 10.1038/sj.embor.embor941

Figure 2.

Figure 2

Functional 'code' of CREB-binding protein/p300 post-translational modifications. Representation of the CREB-binding protein (CBP) and p300 histone acetyl transferases including their functional domains (cysteine/histidine-rich domains (CH1 and CH3); CREB-binding domain (KIX); bromodomain (Br); and acetyl transferase domain (AT)) and some of their post-translational modifications (phosphorylation (P); methylation (Met); and sumoylation (Sumo)). The post-translational modifications activating (in green) or inhibiting (in red) CBP or p300 enzymatic activity (filled circles) or transcriptional activity (empty circles) are shown. The transcription factors for which binding to CBP or p300 is affected by CBP/p300 modifications are also shown. Note that some modifications have only been documented for CBP or for p300. The lines below some modifications indicate the region in which the modification occurs for sites that have not been fully characterized. NR, nuclear receptor superfamily.