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. Author manuscript; available in PMC: 2026 Jun 16.
Published in final edited form as: J Alzheimers Dis. 2026 May 4;111(3):991–1013. doi: 10.1177/13872877261429996

Figure 2. Sleep in 3xTg-AD mice is increased during rest sessions immediately before and after a task.

Figure 2.

a. Box and whiskers (min to max) reflect the proportion of stillness for non-Tg mice with a recording-array (dark blue), 3xTg-AD mice with a recording-array (light green), and 3xTg-AD non-recording-array mice (light purple). 3xTg-AD non-recording-array mice spend significantly less time still during sleep sessions than 3xTg-AD mice with a recording-array. b. 3xTg-AD mice with a recording-array had significantly fewer episodes of sleep but significantly higher proportions of sleep. Sleep in 3xTg-AD mice is similar to non-Tg recording-array mice. Box and whiskers (min to max) proportion of stillness, slow-wave sleep (SWS), and SWS episode length for non-Tg (dark blue) and 3xTg-AD (light green) mice. c. Time to sleep onset and wakefulness is reduced in 3xTg-AD mice. The time spent in SWS is increased in 3xTg-AD mice, but REM sleep is unchanged. d. Same as panel c but for proportions instead of time. e. The number of episodes of REM and SWS did not differ between groups. f. The SWS, but not REM, episode length was greater in 3xTg-AD mice. * p < 0.05, ** p < 0.01, *** p < 0.001.