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. Author manuscript; available in PMC: 2026 Jun 16.
Published in final edited form as: J Alzheimers Dis. 2026 May 4;111(3):991–1013. doi: 10.1177/13872877261429996

Figure 4. Theta-gamma comodulation during SWS is preserved in 3xTg-AD sleep mice and is marginally predictive of spatial reorientation performance the following day.

Figure 4.

a. During SWS adjacent to the spatial reorientation task, cross-frequency (phase-amplitude) coupling between theta phase and low-gamma amplitude in HPC was strong and did not significantly differ between non-Tg sleep mice (Left) and 3xTg-AD sleep mice (Right). b. In the same mice one month later, during a virtual version of the same task (behavioral data previously published1; comodulation data shown here for the first time), theta–gamma comodulation was reduced in 3xTg-AD sleep mice and was significantly lower than in non-Tg sleep mice (see contour on the 3xTg-AD comodulation heatmap).