表 2.
围术期血糖水平与ESCC根治术患者长期总生存的剂量-反应关系
Dose-response relationship of perioperative glucose levels with long-term OS among ESCC patients who underwent radical esophagectomy
| Glucose levels/(mmol/L) | Total，n (%) | Death，n (%) | 5-year survival/% (95%CI) | Adjusted HR (95%CI)a | P valuea |
| CI, confidence interval; ESCC, esophageal squamous cell carcinoma; HR, hazard ratio; OS, overall survival. a, HR, 95% CI and P values were obtained using multivariable Cox proportional-hazard models, adjusting for age, gender, smoking, alcohol consumption, body mass index, presence of comorbidities, tumor location, tumor morphology, pathological tumor-lymph node-metastasis (pTNM) stage, tumor grade, tumor size, margin status, postoperative treatment modality, calendar year of operation, and study center. To evaluate trends in HR, ordinal variables were modeled as single, continuous variables. | |||||
| Preoperative | |||||
| < 7.0 | 4 441 (93.3) | 1 667 (37.5) | 66.5 (64.8-68.1) | Reference | |
| 7.0- < 11.0 | 271 (5.7) | 126 (46.5) | 56.7 (51.0-63.2) | 1.40 (1.17-1.69) | < 0.001 |
| ≥ 11.0 | 50 (1.1) | 21 (42.0) | 60.6 (48.3-76.2) | 1.47 (0.95-2.27) | 0.081 |
| Ptrend | < 0.001 | ||||
| Postoperative | |||||
| < 7.0 | 3 097 (81.3) | 1 086 (35.1) | 66.4 (64.7-68.2) | Reference | |
| 7.0- < 11.0 | 668 (17.5) | 267 (40.0) | 63.0 (59.3-66.9) | 1.35 (1.18-1.55) | < 0.001 |
| ≥ 11.0 | 44 (1.2) | 26 (59.1) | 43.4 (30.5-61.7) | 1.98 (1.34-2.94) | 0.001 |
| Ptrend | < 0.001 | ||||