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Regional Vmax, KD, and KM for 3H-L-arginine BBB L-arginine transport. Values are mean ± SEM for 3–4 animals. Statistical analysis includes an extra-sum-of-squares F-test for best-fit parameters, * indicates p < 0.05 from cortical tissue
| Regional Pharmacokinetic Parameters for BBB 3H-L-arginine transport | |||
|---|---|---|---|
| Region | Vmax (nmol/min/g) | KD (mL/s/g) | KM (µM) |
| Cortical | 5.5 ± 0.6 | 2.1 ± 0.4 | 45 ± 19 |
| Subcortical | 6.9 ± 0.7 | 2.5 ± 0.7 | 48 ± 17 |
| Cerebellum | 9.3 ± 0.9* | 3.2 ± 0.5 | 78 ± 24 |
