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. 2026 Jun 15;17:120. doi: 10.1186/s13293-026-00940-7

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© The Author(s) 2026, modified publication 2026

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Schematic overview of nitric oxide-related metabolites and ratios. Created in BioRender. Dinges, S. (2026) https://BioRender.com/9it7izq. Abbreviations: ADMA, asymmetric dimethylarginine; AGAT, arginine: glycine amidinotransferase; cGMP, cyclic guanosine monophosphate; DDAH, dimethylarginine dimethylaminohydrolase; eNOS, endothelial nitric oxide synthase; NO, nitric oxide; PKG, protein kinase G; SDMA, symmetric dimethylarginine; sGC, soluble guanylate cyclase