Table 2.
Nitric oxide metabolites and ratios stratified by sex and age class (unadjusted)
| Men [n = 58] |
Women [n = 113] |
p sex*age | |||
|---|---|---|---|---|---|
| Median [1st; 3rd quartile] |
β coefficient [95% CI], page | Median [1st; 3rd quartile] |
β coefficient [95% CI], page | ||
| NO metabolites | |||||
| L-arginine [µmol/L], | 67.9 [58.5;82.0] |
0.017 [−0.69 to 0.72]; p = 0.962 |
67.7 [59.4;81.9] |
0.182 [−0.20 to 0.57]; p = 0.349 |
0.677 |
| ≤60 years | 61.3 [52.0;70.8] | 66.6 [63.0;74.4] | |||
| 60–<70 years | 68.4 [63.4;91.3] | 71.3 [65.0;82.0] | |||
| 70–<80 years | 69.5 [58.4;81.7] | 66.3 [58.6;79.7] | |||
| ≥80 years | 63.6 [58.6;74.6] | 74.0 [59.0;86.0] | |||
| L-homoarginine [µmol/L] | 1.33 [1.00;1.85] |
−0.014 [−0.04 to 0.02]; p = 0.340 |
1.22 [0.74;1.61] |
−0.012 [−0.03 to 0.00] p = 0.104 |
0.890 |
| ≤60 years | 1.46 [0.81;2.25] | 1.39 [1.02;1.88] | |||
| 60–<70 years | 1.38 [1.14;1.80] | 1.29 [0.72;1.57] | |||
| 70–<80 years | 1.40 [1.02;1.91] | 1.06 [0.78;1.64] | |||
| ≥80 years | 1.14 [0.87;1.55] | 1.03 [0.68;1.32] | |||
| ADMA [µmol/L] | 0.62 [0.58;0.68] |
0.003 [−0.001 to 0.006]; p = 0.160 |
0.61 [0.55;0.66] |
0.003 [0.001 to 0.005] p = 0.007 |
0.936 |
| ≤60 years | 0.62 [0.61;0.65] | 0.61 [0.54;0.64] | |||
| 60–<70 years | 0.59 [0.53;0.62] | 0.57 [0.52;0.63] | |||
| 70–<80 years | 0.66 [0.62;0.72] | 0.61 [0.57;0.68] | |||
| ≥80 years | 0.61 [0.58;0.64] | 0.67 [0.64;0.71] | |||
| SDMA [µmol/L] | 0.72 [0.58;0.82] |
* 0.013 [0.001 to 0.025]; p = 0.035 |
0.60 [0.52;0.72] |
* 0.009 [0.003 to 0.015] p = 0.002 |
0.568 |
| ≤60 years | 0.66 [0.57;0.95] | 0.52 [0.48;0.60] | |||
| 60–<70 years | 0.59 [0.56;0.72] | 0.59 [0.53;0.70] | |||
| 70–<80 years | 0.75 [0.63;0.92] | 0.62 [0.55;0.75] | |||
| ≥80 years | 0.79 [0.65;0.82] | 0.77 [0.68;1.03] | |||
| L-citrulline [µmol/L] | 42.9 [32.3;51.1] |
0.662 [−0.00 to 1.32]; p = 0.05 |
40.3 [33.0;47.5] |
0.257 [−0.00 to 0.52] p = 0.053 |
0.193 |
| ≤60 years | 34.7 [23.0;45.3] | 37.2 [31.1;45.7] | |||
| 60–<70 years | 34.6 [27.6;50.7] | 39.5 [34.1;45.9] | |||
| 70–<80 years | 42.7 [32.4;52.2] | 40.3 [33.9;46.2] | |||
| ≥80 years | 44.6 [37.9;49.3] | 53.1 [42.4;59.6] | |||
| L-lysine [µmol/L] | 191 [172;213] |
−0.495 [−1.56 to 0.57]; p = 0.357 |
183 [164;205] |
0.413 [−0.26 to 1.08] p = 0.224 |
0.172 |
| ≤60 years | 184 [175;195] | 177 [151;211] | |||
| 60–<70 years | 199 [171;221] | 182 [165;204] | |||
| 70–<80 years | 195 [174;213] | 182 [164;205] | |||
| ≥80 years | 176 [164;182] | 195 [185;199] | |||
| L-ornithine [µmol/L] | 71.9 [59.0;87.6] |
0.245 [−0.62 to 1.11]; p = 0.573 |
71.3 [59.6;82.4] |
0.638 [0.16 to 1.11] p = 0.009 |
0.422 |
| ≤60 years | 61.4 [55.6;67.9] | 63.9 [59.5;73.7] | |||
| 60–<70 years | 68.9 [61.6;85.1] | 66.5 [56.0;81.1] | |||
| 70–<80 years | 81.6 [66.1;89.4] | 72.2 [62.6;82.0] | |||
| ≥80 years | 58.0 [54.4;74.4] | 87.9 [76.8;108] | |||
| Ratios | |||||
| L-arginine/ADMA ratio | 104 [85.3;134] |
−0.459 [−1.66 to 0.75]; p = 0.449 |
117 [97.6;131] |
−0.252 [−0.92 to 0.41] p = 0.454 |
0.762 |
| ≤60 years | 99.1 [80.7;117] | 111 [97.0;132] | |||
| 60–<70 years | 124 [92.6;153] | 123 [109;135] | |||
| 70–<80 years | 102 [85.1;126] | 109 [94.8;124] | |||
| ≥80 years | 104 [95.1;118] | 98.2 [89.9;132] | |||
| L-arginine/L-ornithine ratio | 0.96 [0.76;1.10] |
−0.002 [−0.01 to 0.01], p = 0.673 |
1.00 [0.84;1.21] |
−0.005 [−0.01 to 0.00], p = 0.141 |
0.674 |
| ≤60 years | 1.00 [0.93;1.04] | 1.03 [0.95;1.23] | |||
| 60–<70 years | 1.03 [0.90;1.08] | 1.15 [0.85;1.25] | |||
| 70–<80 years | 0.86 [0.75;1.07] | 0.98 [0.78;1.12] | |||
| ≥80 years | 1.03 [0.81;1.33] | 0.83 [0.75;0.99] | |||
| GABR | 0.60 [0.52;0.71] |
−0.005 [−0.01 to 0.00]; p = 0.078 |
0.65 [0.55;0.75] |
−0.003 [−0.01 to 0.00] p = 0.153 |
0.552 |
| ≤60 years | 0.71 [0.63;0.74] | 0.66 [0.58;0.80] | |||
| 60–<70 years | 0.65 [0.59;0.75] | 0.70 [0.55;0.80] | |||
| 70–<80 years | 0.57 [0.50;0.64] | 0.63 [0.53;0.69] | |||
| ≥80 years | 0.59 [0.53;0.69] | 0.52 [0.44;0.65] | |||
Data is presented as median [1st; 3rd quartile]
Sample size of age groups (men/women): ≤60 years (4/16); 60–<70 years (15/40); 70–<80 years (33/47), ≥ 80 years (6/10)
Results show the regression coefficient β for age and the corresponding 95% confidence interval, or the p-value for the interaction of sex*age
* Model did not meet model assumptions and therefore, data was log-transformed