TABLE 2.
Variable | Group I (n = 14) | Group II (n = 14) |
---|---|---|
Parasite | ||
PC50 (h) | 8 (5-12) | 7 (6-11) |
PC90 (h) | 16 (11-21) | 16 (10-19) |
PCT (h) | 23 (12-24) | 18 (8-20) |
PC12 (%) | 24 (7-51) | 32 (0-56) |
Clinical | ||
FCT (h) | 22 (12-48) | 14 (2-31) |
Hospital stay (days) | 3 (2-3) | 2 (1-3) |
Mortality (no. of patients treated/no. of patients who died) | 0/14 | 2/14 |
Positive blood film day 28 | 1/9 | 0/9 |
Laboratory | ||
Lactate concn (mmol/liter) at 4 h | 2 (1.7-3.4) | 2.6 (1.4-3.6) |
Lactate concn (mmol/liter) at 12 h | 0.9 (0.8-1.6) | 1.6 (1.2-2.5) |
All values except temperature which are means [SDs] and those indicated otherwise are medians (interquartile ranges). PC12, percent fall in parasitemia at 12 h; PC50, time for parasitemia to fall to 50% of the baseline value; PC90, time for parasitemia to fall 90% of the baseline value; PCT, parasite clearance time; FCT, fever clearance time. Group I received 2.4 mg of ARS/kg i.v. followed by 1.2 mg of ARS/kg i.m.; group II received 2.4 mg of ARS/kg i.m. followed by 1.2 mg/kg i.v.