Table 7.

Sex-related differences in skeletal maturation stages across cervical vertebrae (C2–C4) and spheno-occipital synchondrosis (SOS)

Anatomical region	Stage	Female median age (years)	Male median age (years)	p-value
C2	0	10.80	11.19	0.221
	1	11.33	12.51	0.0019
	2	12.64	14.51	< 0.001
	3	15.00	15.75	0.010
	4	19.46	20.75	< 0.001
C3	0	10.84	11.07	0.244
	1	11.30	12.25	0.024
	2	12.74	14.73	< 0.001
	3	15.54	16.52	< 0.001
	4	19.58	21.04	< 0.001
C4	0	10.88	11.39	0.326
	1	11.27	11.93	0.006
	2	13.00	14.73	< 0.001
	3	15.71	16.72	0.005
	4	19.87	21.30	< 0.001
SOS	1	10.88	11.46	0.075
	2	11.47	13.99	< 0.001
	3	13.87	15.47	< 0.001
	4	18.33	19.44	< 0.001
	5	19.33	20.96	< 0.001