TABLE 1.
Pharmacokinetics of amoxicillin and clavulanate after a 30-min infusion of amoxicillin-clavulanate at 1.1 g i.v.a to miniature pigs and comparison with the values for humansb
| Drug and subject | Dose (mg) | Cmax (μg/ml) | Tmax (h) | t1/2 (h) | AUCc (mg · h · liter−1) | Clearance (ml/min) |
|---|---|---|---|---|---|---|
| Amoxicillin | ||||||
| Miniature pigs | 1,000 | 139.7 ± 18.7 | 0.5 | 1.1 ± 0.5 | 108.3 ± 15.8 | 202 ± 35.2 |
| Humansd | 2,000 | 108.3 ± 20.6 | 0.5 | 1.0 | 125.0 | 240 |
| Clavulanate | ||||||
| Miniature pigs | 100 | 11.6 ± 2.0 | 0.5 | 0.9 ± 0.1 | 13.2 ± 3.8 | 178 ± 52.8 |
| Humansd | 200 | 13.8 ± 2.8 | 0.5 | 0.8 | 18.3 | 180 |
a
The dose corresponded to one of 2.2 g for humans.
b
Abbreviations: Cmax, maximum concentration in drug in serum; Tmax, time to maximum concentration of drug in serum.
c
From 0 to 8 h.
d
Data for humans are from Staniforth et al. (21).