TABLE 3.
Ex vivo bactericidal activity of amoxicillin-clavulanate at 1.1 g against the four E. coli strains tested
| Log10 decrease in bacterial counta | Corresponding dilution | All samples from the following times or time intervals (h) from the pharmacokinetic study |
|---|---|---|
| LLP | ||
| 5 | 1:2 | 0-12 |
| 5 | 1:2 and 1:4 | 0-5 |
| 5 | 1:2 to 1:16 | 0.5 |
| 3 | 1:2 to 1:8 | 0-12 |
| 3 | 1:32 | 0.5-1 |
| ILP 425 | ||
| 5 | 1:2 | 0.5, 0.75, 1 |
| 5 | 1:2 to 1:4 | 0.5, 0.75 |
| 4 | 1:2 to 1:8 | 0.5 |
| 3 | 1:2 | 1.5 |
| 2 | 1:4 | 1 |
| 1 | 1:2 | 2 |
| ILP 8425 | ||
| 5 | 1:2 | 0.5-2 |
| 5 | 1:2 to 1:4 | 0.5, 0.75 |
| 5 | 1:2 to 1:8 | 0.75 |
| 3 | 1:2 to 1:8 | 0.75 |
| 2 | 1:2 to 1:16 | 0.5 |
| HLP | ||
| 5 | 1:2 | 0.5, 0.75, 1 |
| 5 | 1:2 to 1:4 | 0.5, 0.75 |
| 3 | 1:8 | 0.5 |
| 2 | 1:2 | 1.5 |
a
Decrease from the starting inoculum.