FIG. 6.

Effect of abscess drainage on imipenem therapy compared to effect of imipenem therapy alone. Groups of three mice each were treated 6 days after inoculation of B. fragilis ATCC 23745 and E. coli ATCC 25922 with daily doses of 384, 768, or 1,536 mg of imipenem per kg divided into 6 (q4h) or 12 (q2h) daily doses for 3 days. A single percutaneous drainage puncture was performed on drained abscesses 30 min after the first imipenem dose had been administered, and the bacterial counts were compared with those of undrained abscesses treated with the same daily doses. The means ± SEMs are given.