TABLE 3.
Summary of enrolled sample profile and results of the assay
| Patient profile | Sequence resultg as determined by:
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No. | Treatment (durationf) | Viral load (log) | CD4 (mm3) | Direct sequence
|
MS-PCR
|
||||||
| M41 | D67 | K70 | L210 | T215 | K219 | M41 | K70 | ||||
| 1 | ZDV + ddC (2.3Y) | 4.6 | 223 | M | N | R | L | I | Q | M | R |
| 2 | Naive | 4.1 | 404 | M | D | K | L | T | K | M | K |
| 3 | Naive | 4.6 | 565 | M | D | K | L | T | K | M | K |
| 4 | Naive | 5.9 | 165 | M | D | K | L | T | K | M | K |
| 5 | Past ZDVa | 5.2 | 90 | M | D | K | M | T | K | M | K |
| 6 | Naive | 5.9 | 0 | M | D | K | L | T | K | M | K |
| 7 | Naive | 4.2 | 371 | M | D | K | L | T | K | M | K |
| 8 | Naive | 5.6 | 284 | M | D | K | L | T | K | M | K |
| 9 | ZDV + 3TC + NVP (1M) | 2.6 | 127 | M | D | K | L | T | K | M/L | Kh |
| 10 | Naive | 4.8 | 306 | M | D | K | L | T | K | M | K |
| 11 | Naive | 5.5 | 226 | M | D | K | L | T | K | M | K |
| 12 | Naive | 6.0 | 61 | M | D | K | L | T | K | M | K |
| 13 | ZDV + ddI (2Y) | 5.3 | 329 | M | D | K | L | T | K | M | K |
| 14 | ZDV + 3TC + NVP (2M) | 2.6 | 106 | M | D | K | L | T | K | M | K |
| 15 | Naive | 3.9 | 441 | M | D | K | L | T | K | M | K |
| 16 | Naive | 5.2 | 869 | M | D | K | L | T | K | M | K |
| 17 | Naive | 5.5 | 0 | M | D | K | L | T | K | M | K |
| 18 | Past ZDVb | 4.9 | 607 | M | D | K | L | T | K | M | K |
| 19 | Naive | 6.0 | 20 | M | D | K | L | T | K | M | K |
| 20 | Naive | 5.5 | 133 | M | D | K | L | T | K | M | K |
| 21 | Past ZDV + ddIc | 4.2 | 389 | M | D | K | L | T | K | M | K |
| 22 | Naive | 4.5 | 416 | M | D | K | L | T | K | M | K |
| 23 | ZDV + ddC (6M) | 5.1 | 489 | M | D | R | L | Y | Q | M/L | Rh |
| 24 | ZDV + ddI/ddC (7M) | 5.3 | 321 | M | D | K | L | T | K | M | K |
| 25 | Naive | 4.6 | 556 | M | D | K | L | T | K | M | K |
| 26 | Naive | 3.4 | 531 | M | D | K | L | T | K | M | K |
| 27 | Naive | 4.2 | 224 | M | D | K | L | T | K | M | K |
| 28 | Naive | 4.1 | 297 | M | D | K | L | T | K | M | K |
| 29 | Naive | 5.8 | 41 | M | D | K | L | T | K | M | K |
| 30 | Naive | 6.2 | 29 | M | D | K | L | T | K | M | K |
| 31 | Naive | 4.5 | 415 | M | D | K | L | T | K | M | K |
| 32 | Naive | 5.4 | 177 | M | D | K | L | T | K | M | K |
| 33 | Past ZDVd | 4.8 | 45 | M | D | K | L | T | K | M | K |
| 34 | Naive | 5.2 | 69 | M | D | K | L | T | K | M | K |
| 35 | Naive | 5.5 | 44 | M | D | K | L | T | K | M | K |
| 36 | ZDV + 3TC/ddI (2Y) | 3.6 | 271 | M | D | K | L | T | K | M | K |
| 37 | ZDV/3TC + d4T (2Y) | 5.5 | 117 | M/L | N | R | L | F | Q | M/L | R |
| 38 | ZDV + 3TC/+ddI + d4T (4Y) | 5.6 | 8 | M | N | R | W | F | K | M | R |
| 39 | ZDV + ddI/ddC (3.5Y) | 3.9 | 6 | L | N | K | W | Y | N | L | K |
| 40 | ZDV + ddI/ddC/3TC (3Y) | 5.1 | 13 | M | D | K | L | I | K | M | K |
| 41 | ZDV + 3TC (3Y) | 3.9 | 373 | M | D | K | L | T | K | M | K |
| 42 | ZDV + ddI/3TC (2.5Y) | 4.6 | 49 | L | N | K | W | Y | K | M/L | Kh |
| 43 | ZDV + 3TC (10M) | 5.5 | 9 | M | D | K | L | T | K | M | K |
| 44 | ZDV + 3TC (0.5M) | 4.7 | 55 | M | D | K | L | T | K | M | K |
| 45 | ZDV + ddC/3TC (2.7Y) | 4.6 | 76 | L | N | R | L | F | Q | L | R |
| 46 | Past ZDV + ddC/3TCc | 4.7 | 1 | M | D | K | L | T | K | M | K |
| 47 | ZDV/+ ddC (4.5M) | 5.2 | 0 | M | N | R | L | F | K | M/L | Rh |
| 48 | Naive | 3.1 | 509 | M | D | K | L | T | K | M | K |
| 49 | Naive | 5.8 | 78 | M | D | K | L | T | K | M | K |
| 50 | ZDV + ddC (1.5M) | 2.6 | NDi | M | D | K | L | T | K | M | K |
| 51 | ZDV + ddI/ddC (2.5Y) | 4.6 | 27 | L | N | K | W | Y | K | L | K |
a
History of 1 months of ZDV monotherapy 2 years ago.
b
History of 2 months of ZDV monotherapy 2 years ago.
c
History of 4 months of ZDV + ddI dual therapy 2 years ago.
d
History of 1 month of ZDV monotherapy 2 years ago.
e
History of 1.4 years of ZDV + ddI/3TC dual therapy 1 year ago.
f
M, months; Y, years.
g
Mutants are indicated in boldface.
h
This case had discordant results between direct sequencing and MS-PCR
i
ND, no data.