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. 2005 Dec 22;4:12. doi: 10.1186/1477-5751-4-12

Table 2.

Linear regression analysis concerning polymorphisms in the MTHFR gene

Gene (polymorphism) R2 ΔR2 % additional explained variance P value
HD CAG .308 - < .0005
HD CAG + MTHFR A1298C .304 .004 - .850
HD CAG + MTHFR C677T .305 .003 - .590
HD CAG + compound heterozygotes .304 .004 - .828

Variance in age at onset for the CAG repeats is indicated as such as well as in combination with the different polymorphisms examined. R2 illustrates the relative improvement of the regression model when the various genotypes are considered in addition to the HD CAG repeats, ΔR2 values quantify these differences. P values refer to R2.