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. 2006 Jan 17;103(4):1000–1005. doi: 10.1073/pnas.0507350103

Fig. 4.

Fig. 4.

Severe disruption of lymphoid development in viable Stat5–/– mice. (A) Thymus and spleen cell counts for 3-week-old Stat5+/+ (filled bars), Stat5–/– (open bars), Il2rg–/– (diagonal hatched bars), and Jak3–/– (horizontal hatched bars) mice. (B) Thymocytes were stained for surface expression of CD4 and CD8 (Left). In addition, CD4/CD8 double-negative cells were gated and stained for surface expression of CD25 and CD44 to distinguish between four developmental stages within that population (Right; DN1, CD44+CD25–; DN2, CD44+CD25+; DN3, CD44–CD25+; DN4, CD44–CD25–). (C–E) Splenocytes were stained for CD4 and CD8 (C), B220 and CD19 (D), and NK1.1 and CD3 (E).