TABLE 1.

Effects of the MIC of moxifloxacin and a concentration equal to four times the MIC on viable counts of 20 S. maltophilia multidrug-resistant nosocomial isolates

Isolate	MIC (μg/ml)	Concn testeda	Individual or mean ± SD log10 change in viable cell count (CFU/ml) at indicated time of growth
			2 h	4 h	6 h	24 h
1	0.25	1 × MIC	−0.40	−0.22	−0.15	+1.90
		4 × MIC	−0.40	−1.30	−1.52	−0.15
2	0.03	1 × MIC	−0.20	−0.60	−1.00	+0.57
		4 × MIC	−0.88	−0.30	−3.78	−4.30
3	4	1 × MIC	0.00	−0.52	−2.00	−1.40
		4 × MIC	−2.11	−2.78	−5.00	−5.00
4	1	1 × MIC	−0.60	−1.43	−1.82	+0.10
		4 × MIC	−1.82	−4.18	−5.00	−4.18
5	4	1 × MIC	−2.12	−2.70	−3.76	−2.12
		4 × MIC	−3.30	−4.90	−6.90	−6.30
6	4	1 × MIC	−0.15	−3.00	−3.00	−2.70
		4 × MIC	−4.20	−6.20	−6.20	−6.20
7	0.5	1 × MIC	−0.54	−0.89	−2.94	0.00
		4 × MIC	−2.90	−5.00	−5.00	−2.90
8	4	1 × MIC	−2.10	−5.00	−5.00	−2.22
		4 × MIC	−5.00	−5.00	−5.00	−5.00
9	2	1 × MIC	−0.10	−3.00	−2.52	−1.15
		4 × MIC	−5.00	−5.00	−5.00	−5.00
10	4	1 × MIC	−1.00	−2.40	−3.00	−3.84
		4 × MIC	−5.00	−5.00	−5.00	−5.00
11	4	1 × MIC	−3.00	−2.70	−3.22	−3.22
		4 × MIC	−5.00	−5.00	−5.00	−5.00
12	2	1 × MIC	−2.90	−4.90	−5.00	−1.60
		4 × MIC	−5.00	−5.00	−5.00	−5.00
13	1	1 × MIC	−0.48	−0.88	−2.00	+1.43
		4 × MIC	−1.00	−2.30	−4.30	−1.60
14	4	1 × MIC	−0.73	−2.90	−3.30	0.00
		4 × MIC	−4.90	−4.90	−4.90	−3.90
15	0.25	1 × MIC	−1.00	−1.22	−2.10	0.00
		4 × MIC	−4.00	−4.10	−5.00	−2.00
16	2	1 × MIC	−0.30	−0.43	−0.60	+0.57
		4 × MIC	−2.06	−2.06	−2.43	+1.10
17	2	1 × MIC	−2.60	−4.78	−5.00	−2.76
		4 × MIC	−5.00	−5.00	−5.00	−5.00
18	0.25	1 × MIC	+1.00	+1.00	+1.00	+1.00
		4 × MIC	−1.00	−1.00	−1.52	−2.30
19	0.5	1 × MIC	−0.12	−1.12	−2.30	+1.40
		4 × MIC	−0.70	−3.60	−5.00	+0.90
20	0.06	1 × MIC	+0.30	0.00	+0.85	+2.00
		4 × MIC	−0.12	−0.06	−0.06	+2.00
1-20		1 × MIC	−0.86 ± 1.11	−1.89 ± 1.71	−2.39 ± 1.82	−0.73 ± 2.11
		4 × MIC	−3.45 ± 2.49b	−4.22 ± 2.41c	−4.83 ± 2.17d	−3.78 ± 2.99e

^aMoxifloxacin was used at the MIC (1 × MIC) and at a concentration equivalent to four times the MIC (4 × MIC).

^bP = 0.001.

^cP = 0.029.

^dP = 0.002.

^eP = 0.004.