TABLE 2.
Therapeutic efficacy of ART-SP in patients with uncomplicated malaria
| Endpointa | No. of patients (n = 22)b | % of patients (95% CI) | Clearance time (days) (mean ± SD [range]) |
|---|---|---|---|
| Primary | |||
| Day 14 ACPR | 20 | 100 (83.2-100) | |
| Day 28 ACPR | 17 | 89.5 (66.9-98.7) | |
| ETF | 0 | 0 | |
| Day 28 LTF | 2c | 10.5 (1.3-33.1) | |
| Secondary | |||
| FCT | 1.4 ± 0.6 (1-3) | ||
| PCT | 1.1 ± 0.2 (1-2) | ||
| Hb | 12 | 70.6 (44.0-89.7) |
a
ACPR, adequate clinical and parasitological response; ETF, early treatment failure; LTF, late treatment failure; FCT, fever clearance time; PCT, parasite clearance time; Hb, hematological response.
b
Three patients were excluded from evaluation on days 2, 7, and 28 for all end points except LTF.
c
Late treatment failure occurred on days 21 and 28.