TABLE 3.

Frequency of pvdhfr-encoded mutations among clinical isolates of P. vivax in Papua

Trial no.	Sequence polymorphisma at position:							No. of mutations	Therapeutic response (SP-containing regimen)b
	33	50	57	58	61	117	173
G806	P	N	F	S	T	S	I	0	ACPR (CQ-SP)
G903	P	N	F	S	T	S	I	0	LTF (CQ-SP)
G104	P	N	F	S	T	S	I	0	ACPR (CQ-SP)
G2060	P	N	F	S	T	S	I	0	ACPR (ART-SP)
G2069	P	N	F	S	T	S	I	0	ACPR (ART-SP)
G058	P	N	F	S	T	S/T	I	Mixed (0 and 1)	CQ
G965	P	N	F	S	T	N	I	1	ACPR (CQ-SP)
G359	P	N	F	R	T	N	I	2	CQ
G457	P	N	F	R	T	N	I	2	CQ
G535	P	K	F	S	T	N	I	2	CQ
G126	P	N	F	R	T	N	I	2	ACPR (CQ-SP)
G1040	P	N	F	R	T	N	I	2	ACPR (ART-SP)
G743	P	N	F	R	T	N	I	2	CQ
G2028	P	N	F	R	T	N	I	2	ACPR (ART-SP)
G2041	P	N	F	R	T	N	I	2	ACPR (ART-SP)
G2067	P	N	F	R	T	N	I	2	ACPR (ART-SP)
G2090	P	N	L	S	T	T	I	2	ACPR (ART-SP)
G2091	P	K	F	S	T	N	I	2	ACPR (ART-SP)
G2099	P	N	F	R	T	N	I	2	ACPR (ART-SP)
G2110	P	N	F	R	T	N	I	2	ACPR (ART-SP)
G273	P	N	L	R	T	T	I	3	CQ
G852	P	N	L	R	M	T	I	4	LTF (SP)
G1015	P	N	L	R	M	T	I	4	LTF (ART-SP)
G2042	P	N	L	R	M	T	I	4	LTF (ART-SP)
G2095	P	N	L	R	M	T	I	4	ACPR (ART-SP)
G2022	P/S	N	F/L	R/S	M/T	T	I	Mixed (1 and 4)	ACPR (ART-SP)

^aWild-type amino acids are in roman-type, previously described polymorphisms are in italics, and novel polymorphisms are in bold type.

^bLTF, late treatment failure; CQ alone, treated only with CQ.