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Characterization of A/WS/33 (H1N1) virus-associated NA enzymea
| Enzyme | Substrate (MUNANA)
|
Ki (nM)
|
||
|---|---|---|---|---|
| Km (μM) | Relative Vmax | Oseltamivir carboxylate | Zanamivir | |
| Wild type (274His) | 31 | 1 | 0.3 | 0.1 |
| Mutant (274Tyr) | 52 | 0.5 | 10.5 | 0.3 |
Values were means of data from three or more independent experiments. Standard deviations were less than 6% of the mean value.
